Skripsi

Optimization of antimalarial activity of endophytic fungal extract of karamuntiang plant (rhodomyrtus tomentosa) aspergillus flavofurcatus rktd1 grown on grain media / Finkka Dhiyausyifa Setiady

Abstrak
The endophytic fungus Aspergillus flavofurcatus RKTD1 from karamuntiang (Rhodomyrtus tomentosa) showed antimalarial potential but was not yet on par with artemisinin. The one strain many compound (OSMAC) method can increase the diversity of secondary metabolite compounds. In this study macroscopic microscopic and molecular identification of RKTD1 fungal isolates cultivation on grain media extraction using ethyl acetate solvent phytochemical testing data analysis measurement of antimalarial activity and LC-MS testing were carried out. The endophytic fungal isolates of RKTD1 were identified as A. flavofurcatus. Cultivation in brown rice medium produces the highest yield and corn medium produces the lowest yield. Corn ethyl acetate extract RKTD1 contains alkaloids flavonoids steroids terpenoids and has the best antimalarial activity. Statistical analysis showed significant differences (1) between groups (white rice corn and artemisinin extract) at concentrations of 5 mg/mL and (2) between all concentration pairs tested (5 1 0.1 0.01 mg/mL). It was found that 3 antimalarial compounds in corn RKTD1 ethyl acetate extract were suspected to play a role in this activity.

Informasi Detail

DDC

SKRIPSI DIGITAL

Prodi

Universitas Negeri Malang. Program Studi Bioteknologi, 2025.

Deskripsi Fisik

4 hlm. : ilus.

Bahasa

No Reg

3922/RS/25

Edisi

Skripsi (Sarjana)--Universitas Negeri Malang. 2025

Subjek

1. EXTRACT OF KARAMUNTING PLANT - RHODOMYRTUS TOMENTOSA
2. GRAIN MEDIA - GROWN

Pembimbing

1. Dr. Muh. Ade Artasasta, S.si; Dwi Listyorini, M.si, D.sc

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